MLB average salary up 3.8 percent to $3.2 million

NEW YORK (AP) — Baseball's average salary increased 3.8 percent this year to a record $3.2 million.

According to final figures released Friday by the Major League Baseball Players Association, the rise was the steepest since 2007. The boost was helped by an increase in the minimum salary from $414,000 to $480,000.

The New York Yankees had the highest average for the 14th consecutive season at $6.88 million, rising after consecutive declines from a peak of $7.66 million when they won the World Series in 2009.

The Los Angeles Dodgers rose from 13th to second at $5.55 million and Texas from 15th to fifth at $4.89 million.

At nearly $685,000 Houston had the lowest average since the 2006 Florida Marlins.

Read More..

U. S. and Russia to Meet on Syrian Conflict

DUBLIN — A new round of diplomacy on the conflict in Syria will begin on Thursday afternoon when Lakhdar Brahimi, the United Nations special envoy, hosts an unusual three-way meeting with Secretary of State Hillary Rodham Clinton and the Russian foreign minister, Sergey V. Lavrov.

The session, which is being held on the margins of a meeting on European security, comes amid reports of heightened activity at Syria’s chemical weapons sites and signs that Russia may be shifting its position on a political transition in Syria.

“Secretary Clinton has accepted an invitation by U.N. Special Envoy Brahimi for a trilateral meeting on Syria this afternoon with Mr. Brahimi and Russian Foreign Minister Lavrov,” a senior State Department official said Thursday morning.

This is not the first time that American and Russian consultations have spurred hopes of a possible breakthrough. In June, Mrs. Clinton, Mr. Lavrov and the United Nations’s envoy on the Syrian crisis at the time, former United Nations Secretary General Kofi Annan, appeared to be close to an agreement that a transitional government should be established and that President Bashar al-Assad give up power.

But that seeming understanding quickly broke down, with American officials complaining privately that the Russian side had pulled back from the deal. A major sticking point, it later emerged, was the American insistence that the United Nations Security Council authorize steps to pressure Mr. Assad if he refused to go along under Chapter 7 of the United Nations Charter, which could be used to authorize tougher economic sanctions and, in theory, the use of force.

It remained to be seen if the new round of negotiations would be more successful.

On the one hand, the military situation on the ground appears to be shifting in the rebels’ favor. Some Russian officials reportedly no longer believe that Mr. Assad will succeed in holding on to power and may have a new interest in working out arrangements for a transition. The changing battlefield, some experts say, may have led to a softening of the Russian position.

A senior Turkish official said that after President Vladimir V. Putin of Russia and Prime Minister Recep Tayyip Erdogan of Turkey recently met in Istanbul that Moscow was “softening” its “political tone” and would look for ways of getting Mr. Assad to relinquish power.

On the other hand, it was possible that Mr. Lavrov had, in effect, merely agreed to meet so that Russia could maintain influence over the discussions on Syria and find out what exactly Mr. Brahimi was prepared to propose.

There were indications on Thursday that Russian officials see the positions of Washington and Moscow on Syria moving slightly closer.

Deputy Foreign Minister Gennady Gatilov of Russia expressed satisfaction in a Twitter message that the United States was moving to designate Al Nusra Front, a Syrian opposition group seen by American experts as linked to Al Qaeda, as an international terrorist organization.

The aim of the American move, which is expected soon, would be to isolate radical foes of the Assad government.

With the rebels making gains on the ground, American officials have been trying to ensure that military developments do not outpace political arrangements for a possible transition. American officials have hinted that the United States would upgrade relations with the Syria opposition, possibly to formal recognition, if the coalition made progress on a political structure by the time of a meeting of the so-called Friends of Syria in Morocco.

But emerging policy on the Al Nusra Front also acknowledges Russia’s longstanding argument that the Syrian opposition includes radical jihadists. Mr. Gatilov said that the American step “reflects understanding of the danger of escalating terrorist activity in Syria.”

A lawmaker with the dominant party, United Russia, told British legislators visiting Moscow that Russia saw Mr. Assad’s government struggling. “We think that the Syrian government should execute its functions,” he said, according to the Interfax news service. “But time shows that this task is beyond its strength.”

Dimitri K. Simes, a Russia expert the Center for the National Interest in Washington, said, based on conversations with top officials, that Russia has indeed softened its position in light of military setbacks for the Assad government, and it is now understood that neither Mr. Assad nor his close associates would take a central role in a new government.

However, he said Russia still wanted Iran to take part in negotiations about the transition. Iran’s presence, he said, would reassure Alawites, the Shiite Muslim minority of Mr. Assad and the core of the military, that they would be protected in the change of government.

Michael R. Gordon reported from Dublin, and Ellen Barry from Moscow. Anne Barnard contributed reporting from Beirut, Lebanon.

Read More..

Apple and Samsung return to court to battle over $1 billion verdict

Read More..

Bryant eclipses 30,000, Lakers beat Hornets 103-87

NEW ORLEANS (AP) — Kobe Bryant grinned and uttered the word "irony" as he considered the fact that the team that drafted him nearly 17 years ago was his opponent on the night he eclipsed a scoring milestone to join an exclusive club of NBA greats.

It's easy to forget that it was the Hornets who drafted and then traded Bryant away back in 1996.

In the years since, the Hornets have changed cities, from Charlotte to New Orleans, and Bryant has become one of five players in NBA history to score 30,000 points, surpassing the mark with a 29-point performance that helped the Lakers to a 103-87 triumph Wednesday night.

"It's funny how sports always seems to kind of have that connectivity, in some shape, form or fashion," Bryant said. "It just always seems to come full circle."

Bryant entered the game needing 13 points to make history and no one doubted he would get it. NBA Commissioner David Stern, who happened to be making a scheduled visit with new Hornets owner Tom Benson, offered Bryant a congratulatory hand shake before tip-off.

Bryant had 17 points by halftime, eclipsing the 30,000-mark with a short jumper in the paint over Robin Lopez late in the first half. That might have been the least spectacular of his baskets, which included the usual array of soaring dunks, demoralizing transition 3-pointers and twisting, off-balance jumpers.

The only other players to score more than 30,000 are Kareem Abdul-Jabbar, Karl Malone, Michael Jordan and Wilt Chamberlain.

"It's pretty awesome," Bryant said. "These are players I respect tremendously and obviously grew up idolizing and watching and learned a great deal from."

When Lakers coach Mike D'Antoni was asked before tipoff about Bryant's impending milestone, the coach joked, "That just means he is old."

In fact, at 34, Bryant is younger than the other four were when they hit the mark, but Bryant also turned pro at 18, and is in his 17th season.

"Honestly, I don't know why I'm still working as hard as I am after 17 years," Bryant said. "That's the thing that I'm most proud of — every year, every day working hard at it. It's a lot of years, a lot of work."

Dwight Howard added 18 points and five blocked shots for the Lakers, who trailed 48-47 at halftime, but seized control with a 13-0 run to open the third quarter, and the lead grew as large as 20 in the fourth.

Ryan Anderson scored 31 points, hitting 5 of 8 3-pointers for the Hornets, who were playing their ninth straight game without top overall draft choice Anthony Davis. Greivis Vasquez added 16 points, while Lopez scored 15 points and blocked five shots.

Antawn Jamison scored 15 and Metta World Peace 11, and Chris Duhon had 10 assists for Los Angeles, which is playing without Steve Nash and Pau Gasol and won for only the second time on the road this season. The Hornets fell to 3-7 at home and lost for the 10th time in 12 games overall.

The Hornets led from early in the first quarter until halftime, going up by as many as eight points when Al-Farouq Aminu slammed down an alley-oop lob from Vasquez, energizing the largest crowd of the season at the New Orleans Arena.

Bryant helped the Lakers trim their deficit after that, hitting five free throws and his milestone on 3-foot jumper in the last 2:15 of the second quarter.

Jamison opened the third-quarter onslaught with 3, Howard followed with a fast-break layup and Bryant had two straight fast-break dunks, one of which he created with a steal. Howard finished the surge with a layup.

"I just didn't think our defense was there, especially that first five or six minutes of the third quarter," Hornets coach Monty Williams said. "Our defense was really poor, and we can't afford those lapses."

After the game, Bryant sat in his locker, reflecting on the elite company he now keeps in NBA history, and the things he sees in younger, prolific scoring stars like Oklahoma City's Kevin Durant, whom the Lakers will face on Friday night, and who could very well join the 30,000-point club at the rate he's going.

One common characteristic, Bryant said, is an apparent immunity to both pressure and criticism.

"Scorers kind of have a fighter-pilot mentality. We're a different breed," he said. "But there are different positions. We scored in a myriad of ways. We all went about it differently in different situations. It's fun to see."

NOTES: Before attending the game, Stern toured the headquarters of the New Orleans Saints, also owned by Benson, and saw how Benson's plans for the NBA franchise were taking shape. New construction has begun on additions that will also accommodate Hornets offices and practice courts. .... Stern said he was pleased to be able to also see Bryant surpass the 30,000-point mark in person. "As a talent, a competitor, I think that he is up there on the pedestal with Michael Jordan," Stern said. "He is one of the greatest." ... Stern also discussed the possibility of a team name change for New Orleans, something Benson has said he wants since buying the club last spring. Stern says the club has not yet applied for a name change but that the league would likely accept whatever name the Hornets want and expedite the transition.

Read More..

Well: Running in Reverse

This column appears in the Dec. 9 issue of The New York Times Magazine.

Backward running, also known as reverse or retro running, is not as celebrated as barefoot running and will never be mistaken for the natural way to run. But a small body of science suggests that backward running enables people to avoid or recover from common injuries, burn extra calories, sharpen balance and, not least, mix up their daily routine.

The technique is simple enough. Most of us have done it, at least in a modified, abbreviated form, and probably recently, perhaps hopping back from a curb as a bus went by or pushing away from the oven with a roasting pan in both hands. But training with backward running is different. Biomechanically, it is forward motion’s doppelgänger. In a study published last year, biomechanics researchers at the University of Milan in Italy had a group of runners stride forward and backward at a steady pace along a track equipped with force sensors and cameras.

They found that, as expected, the runners struck the ground near the back of their feet when going forward and rolled onto the front of their feet for takeoff. When they went backward though, they landed near the front of their feet and took off from the heels. They tended to lean slightly forward even when running backward. As a result, their muscles fired differently. In forward running, the muscles and tendons were pulled taut during landing and responded by coiling, a process that creates elastic energy (think rubber bands) that is then released during toe-off. When running backward, muscles and tendons were coiled during landing and stretched at takeoff. The backward runners’ legs didn’t benefit from stored elastic energy. In fact, the researchers found, running backward required nearly 30 percent more energy than running forward at the same speed. But backward running also produced far less hard pounding.

What all of this means, says Giovanni Cavagna, a professor at the University of Milan who led the study, is that reverse running can potentially “improve forward running by allowing greater and safer training.”

It is a particularly attractive option for runners with bad knees. A 2012 study found that backward running causes far less impact to the front of the knees. It also burns more calories at a given pace. In a recent study, active female college students who replaced their exercise with jogging backward for 15 to 45 minutes three times a week for six weeks lost almost 2.5 percent of their body fat.

And it aids in balance training — backward slow walking is sometimes used as a therapy for people with Parkinson’s and is potentially useful for older people, whose balance has grown shaky.

But it has drawbacks, Cavagna says — chiefly that you can’t see where you’re going. “It should be done on a track,” he says, “or by a couple of runners, side by side,” one facing forward.

It should be implemented slowly too, because its unfamiliar motion can cause muscle fatigue. Intersperse a few minutes periodically during your regular routine, Cavagna says. Increase the time you spend backward as it feels comfortable.

The good news for serious runners is that backward does not necessarily mean slow. The best recorded backward five-kilometer race time is 19:31, faster than most of us can hit the finish line with our best foot forward.

Read More..

Steven A. Cohen Is Absent at Art Basel Miami Beach

Katie Orlinsky for The New York Times

Art Basel's V.I.P. opening at the Miami Beach Convention Center on Wednesday, seen through Olafur Eliasson's work, "Your Shared Planet."

MIAMI BEACH — The opening of Art Basel Miami Beach, under way here this week, looked like the start of the most glamorous doorbuster sale in history, with hundreds of V.I.P.’s streaming into the convention center wearing high-end resort casual, ready to rummage through more than 200 of the world’s most prestigious galleries.

Among the shoppers were prominent collectors like Peter Brant, the newsprint executive, who strolled with the actor Owen Wilson. At the Gagosian Gallery booth, P. Diddy gave a hug to the casino mogul Steve Wynn beside a $2 million sculpture by Roy Lichtenstein.

But one notable titan of this realm was missing: Steven A. Cohen, the hedge fund billionaire, who in less than six years has acquired one of the market’s richest troves, with works by Manet, Monet, Jackson Pollock, Andy Warhol and Damien Hirst, to cite just a few.

In recent weeks, his name has surfaced with the legal troubles of Mathew Martoma, whom federal prosecutors have accused of insider trading while working at Mr. Cohen’s firm in Connecticut, SAC Capital Advisors. Mr. Cohen has not been charged with any wrongdoing, but there has been speculation that the government hopes to leverage the case against Mr. Martoma into charges against Mr. Cohen.

Does that possibility worry luminaries in the art world? A quick survey of gallerists, advisers and collectors suggests it depends on whom you ask. Plenty of people doubt that Mr. Cohen will ever be in genuine jeopardy and others think that even if he is, the art market now has so many well-heeled players that the absence of one buyer wouldn’t have a notable impact.

Then there were the gallery owners who had sold works to Mr. Cohen. As a general rule, the more business they have conducted with the man, the more worried they are likely to be.

“It’s disconcerting,” said Timothy Blum, co-owner of Blum & Poe, a gallery in Los Angeles. “We’re talking about a lot of liquid,” he added, meaning money. “A lot of liquid. I’ve never calculated it out, but he’s responsible for a significant percent of our business.”

For Mr. Blum and other elite gallery owners, there is sincere dread at the notion, however remote, that Mr. Cohen may one day be sidelined. Known in the securities world for astounding investment returns and an occasionally volcanic temper, he is described by dealers as the ideal collector — warm, dedicated, eager to take home the best pieces and unafraid to spend what it takes.

“We would absolutely hate to have him not active in the market, I can wholeheartedly say that,” said David Zwirner, who owns a gallery that bears his name in the Chelsea section of Manhattan. “This man is a friend of mine. I called him last week — ‘How are you? What’s going on?’ I think the art world is rooting for him. I’m rooting for him. I wish he were here right now.”

Two years ago, Mr. Cohen arrived at Mr. Zwirner’s booth in the opening minutes of the V.I.P. preview day and dropped $300,000 on a work by Adel Abdessemed, an Algerian-born artist who lives in Paris. Within the hour, Mr. Cohen had reportedly spent an additional $180,000 at Blum & Poe for a work by Tim Hawkinson called “Bike.”

The fair didn’t officially open until Thursday, but on Wednesday the convention center was already radiating an air of unabashed opulence. Cavernous, and crammed with product, the place is a kind of Costco for the rich, where the prices range from a low of a few thousand dollars to a high of “we don’t give out that information.” Women pushing carts handed out free flutes of Ruinart Champagne, the official Champagne of Art Basel Miami Beach.

Will Ferrell, the comedian, was one of handful of celebrities in the crowd. Wearing mirrored aviator sunglasses and sporting a green shirt with “Ireland” emblazoned on the back of the neck, he said he already knew what he wanted.

Read More..

Serbian Ambassador to NATO Is Said to Commit Suicide

PARIS — The Serbian ambassador to NATO, Branislav Milinkovic, jumped to his death from a multistory parking garage on Tuesday afternoon at the Brussels airport, diplomats said Wednesday.

Reuters

Branislav Milinkovic, Serbia's ambassador to NATO, sits at the alliance headquarters in Brussels Dec. 14, 2006.

Mr. Milinkovic, 52, a respected diplomat, lawyer and intellectual appointed to the ambassadorship in 2009, was at the airport to meet a visiting Serbian delegation, officials said. B92, an independent broadcaster in Belgrade, Serbia, reported that the country’s assistant foreign minister, Zoran Vujic, was with Mr. Milinkovic at the time and witnessed his death.

Serbian officials said that the motive was not known, and that Mr. Milinkovic gave no sign of what he intended in the moments before he leapt to his death.

Diplomats attending a two-day meeting of NATO foreign ministers in Brussels said they were shocked by the news. Serbia is not a member of the military alliance, but it belongs to a group of countries that cooperates with NATO on military and security issues.

Oana Lungescu, a spokeswoman for the alliance, said by telephone from Brussels that Mr. Milinkovic was a jovial and engaging man known for his gentle manner, and that he was widely liked and admired at NATO headquarters, where he had been recently seen playing tennis. He had a wife, who was in Dublin at the time of his death, and a son, B92 said.

When Serbia, the largest state to emerge from the disintegration of Yugoslavia, was ruled by the strongman Slobodan Milosevic in the 1990s, NATO conducted a bombing campaign to force Mr. Milosevic to withdraw Serbian forces from the breakaway region of Kosovo. Mr. Milinkovic was an opposition activist during Mr. Milosevic’s rule, and he became a diplomat after his overthrow in 2000, helping to rebuild friendly ties with Western Europe.

“Everyone is totally shocked to hear what happened,” Ms. Lungescu said. “He was a totally open and lovely man and made an important contribution toward rapprochement between Serbia and NATO, making great efforts to bridge over a difficult history and to move forward rather than backward.”

Read More..

Facebook’s Instagram cuts support for key Twitter integration

SAN FRANCISCO (Reuters) – Facebook Inc’s recently acquired photo-sharing service, Instagram, removed a key element of its integration with Twitter, signaling a deepening rift between two of the Web’s dominant social media companies.

Instagram’s Chief Executive Kevin Systrom said Wednesday his company turned off support for Twitter “cards” in order to drive Twitter users to Instagram’s own website. Twitter “cards” are a feature that allows multimedia content like YouTube videos and Instagram photos to be embedded and viewed directly within a Twitter message.

Instagram’s move marked the latest clash between Facebook and Twitter since April, when Facebook, the world’s no. 1 social network, outbid Twitter to nab fast-growing Instagram in a cash-and-stock deal valued at the time at $ 1 billion. The acquisition closed in September for roughly $ 715 million, due to Facebook’s recent stock drop.

The companies’ ties have been strained since. In July, Twitter blocked Instagram from using its data to help new Instagram users find friends.

Beginning earlier this week, Twitter’s users began to complain in public messages that Instagram photos did not seem to display properly on Twitter’s website.

Instagram CEO Kevin Systrom confirmed Wednesday that his company had decided that its users should view photos on Instagram’s own Web pages and took steps to change its policies.

“We believe the best experience is for us to link back to where the content lives,” Systrom said in a statement, citing recent improvements to Instagram’s website.

“A handful of months ago, we supported Twitter cards because we had a minimal web presence,” Systrom said, noting that the company has since released new features that allow users to comment about and “like” photos directly on Instagram’s website.

The move escalates a rivalry in the fast-growing social networking sector, where the biggest players have sought to wall off access to content from rival services and to their ranks of users. Photos are among the most popular features on both Facebook and Twitter, and Instagram’s meteoric rise in recent years has further proved how picture-sharing has become a key front in the battle for social Internet supremacy.

Instagram, which has 100 million users, allows consumers to tweak the photos they take on their smartphones and share the images with their friends, a feature that Twitter has reportedly also begun to develop. Twitter’s executive chairman Jack Dorsey was an investor in Instagram and hoped to acquire it before Facebook CEO Mark Zuckerberg tabled a successful bid.

When Zuckerberg announced the acquisition in an April blog post, he said one of Instagram’s strengths was its inter-connectivity with other social networks and pledged to continue running it as an independent service.

“We think the fact that Instagram is connected to other services beyond Facebook is an important part of the experience,” Zuckerberg wrote. “We plan on keeping features like the ability to post to other social networks.”

A Twitter spokesman declined comment Wednesday, but a status message on Twitter’s website confirmed that users are “experiencing issues,” such as “cropped images” when viewing Instagram photos on Twitter.

Systrom noted that Instagram users will be able to “continue to be able to share to Twitter as they originally did before the Twitter Cards implementation.”

(Reporting By Alexei Oreskovic and Gerry Shih; Editing by Nick Zieminski)

Social Media News Headlines – Yahoo! News

Read More..

Athletes lose medals; Armstrong decision pending

LAUSANNE, Switzerland (AP) — Eight years after winning Olympic medals in Athens, four track and field athletes from eastern Europe were ordered to hand them back Wednesday because of positive doping tests, while Lance Armstrong can hold onto his bronze medal from the 2000 Sydney Games a little while longer.

The International Olympic Committee executive board disqualified four athletes whose 2004 Athens doping samples were retested this year and came back positive for steroids, including shot put gold medalist Yuriy Bilonog of Ukraine.

Also stripped of medals were hammer throw silver medalist Ivan Tskikhan of Belarus and two bronze medalists — women's shot putter Svetlana Krivelyova of Russia and discus thrower Irina Yatchenko of Belarus.

The IOC held off stripping Armstrong of the bronze he won 12 years ago in the cycling road time trial in Sydney, citing procedural reasons for the delay.

IOC leaders want Armstrong's medal back after the damning U.S. Anti-Doping Agency report that painted Armstrong as a systematic drug cheat. The International Cycling Union recently stripped Armstrong of his seven Tour de France titles from 1999-2005.

But the IOC said it must wait for UCI, the cycling's governing body, to formally notify Armstrong of the loss of all his results since August 1998. The IOC wants to avoid any legal problems in connection with the eight-year statute of limitations in the Olympic rules.

"The IOC today will not move," IOC President Jacques Rogge said at a news conference following a two-day board meeting in Lausanne. "We need to have the situation whereby the UCI notifies officially Mr. Armstrong of the fact that he will be disqualified, declared ineligible and that he should hand over his medal.

"This is a legal obligation not for the IOC but for the International Cycling Union. When he will be notified, Mr. Armstrong will have 21 days to launch an appeal if he wishes. It is only after this period of 21 days that the IOC can legally take action."

The case of a fifth bronze medalist, weightlifter Oleg Perepechenov of Russia, is pending.

The IOC said it will ask the International Association of Athletics Federations to get the four medals back and readjust the results and rankings from the Athens Games.

Until then, no decision will be taken on reallocating the medals. Adam Nelson of the United States finished second in the shot put in Athens behind Bilonog and would stand to move up to gold.

The intention of the IOC to wipe Armstrong from the Olympic record books remains clear.

"Absolutely," IOC vice president Craig Reedie of Britain told The Associated Press. "If the UCI have the ability to remove all these titles, we should have the ability to remove a bronze medal. Once they go through their procedures, then we'll go through ours."

Armstrong finished behind winner and U.S. Postal Service teammate Vyacheslav Ekimov of Russia and Jan Ullrich of Germany in Sydney. The IOC has no plans to reallocate Armstrong's bronze medal, just as the UCI decided not to declare any winners for the Tour titles once held by the American.

In August, the IOC stripped Tyler Hamilton, a former Armstrong teammate, of his time-trial gold medal from the 2004 Athens Olympics after he admitted to doping.

The Athens Games were already considered the dirtiest on record, producing 26 doping cases and catching six medalists — including two gold winners — at the time. The retroactive tests bring the number of Athens cases to 31, including 11 medal winners and three gold medalists.

Since Athens, the IOC has been storing doping samples from each Olympics for eight years to allow for retesting when new detection methods become available. Last year, under prodding from the World Anti-Doping Agency, the IOC reanalyzed about 100 samples from Athens.

The IOC said Bilonog and Krivelyova tested positive for oxandrolone, while the samples from Tsikhan and Yatchenko were positive for methandienone.

Bilonog's disqualification means that both shot put winners in Athens have been disqualified for doping: Women's champion Irina Korzhanenko of Russia was stripped of gold at the games after testing positive for stanozolol.

The IAAF held the 2004 shot put competition in Ancient Olympia, in what had been intended as a symbolic and uplifting return to the birthplace of the Olympics.

Read More..

Study Raises Questions on Coating of Aspirin

While aspirin may prevent heart attacks and strokes, a commonly used coating to protect the stomach may obscure the benefits, leading doctors to prescribe more expensive prescription drugs, according to a study published Tuesday in the journal Circulation.

The conclusion about coated aspirin was only one finding in the study, whose main goal was to test the hotly disputed idea that aspirin does not help prevent heart attacks or stroke in some people.

For more than a decade, cardiologists and drug researchers have posited that anywhere from 5 to 40 percent of the population is “aspirin resistant,” as the debated condition is known. But some prominent doctors say that the prevalence of the condition has been exaggerated by companies and drug makers with a commercial interest in proving that aspirin — a relatively inexpensive, over-the-counter drug whose heart benefits have been known since the 1950s — does not always work.

The authors of the new study, from the University of Pennsylvania, claim that they did not find a single case of true aspirin resistance in any of the 400 healthy people who were examined. Instead, they claim, the coating on aspirin interfered with the way that the drug entered the body, making it appear in tests that the drug was not working.

The study was partly financed by Bayer, the world’s largest manufacturer of brand-name aspirin, much of which is coated.

Aside from whether coating aspirin conceals its effects in some people, there is little evidence that it protects the stomach better than uncoated aspirin, said Dr. Garret FitzGerald, chairman of pharmacology at the University of Pennsylvania and one of the study’s authors.

“These studies question the value of coated, low-dose aspirin,” he said in a statement accompanying the article. “This product adds cost to treatment, without any clear benefit. Indeed, it may lead to the false diagnosis of aspirin resistance and the failure to provide patients with an effective therapy.”

In a statement, Bayer took issue with some of the study’s conclusions and methods and said previous studies of coated aspirin, also called enteric-coated aspirin, have been shown to stop blood platelets from sticking together — which can help prevent heart attacks and stroke — at levels comparable to uncoated aspirin. Bayer also noted that the price difference between its coated and uncoated aspirin was negligible, although Dr. FitzGerald argued there was no reason patients should use anything other than uncoated generic aspirin, which is cheaper.

“When used as directed,” the company said, “both enteric and nonenteric coated aspirin provides meaningful benefits, is safe and effective and is infrequently associated with clinically significant side effects.”

Although researchers had long observed that, as is true with most drugs, aspirin’s effects varied among patients, the existence of “aspirin resistance” gained currency in the 1990s and early 2000s. One often-cited study, published in 2003, found that about 5 percent of cardiovascular patients were aspirin-resistant and that that group was more than three times as likely as those not aspirin-resistant to suffer a major event like a heart attack.

But some said the popularity of aspirin resistance got a boost in part because of the development of urine and blood tests to measure it and the arrival on the market of drugs like Plavix, a more expensive prescription drug sold by Bristol-Myers Squibb that also thins the blood.

In the most recent study, the patients who initially tested positive for aspirin resistance later tested negative for it and by the end of the study, Dr. FitzGerald said, none of the patients showed true resistance. “Nobody had a stable pattern of resistance that was specific to coated aspirin,” he said. If resistance to aspirin exists, he said, “I think that the incidence is vanishingly small.”

Dr. Eric Topol, one of the authors of the 2003 study, said he strongly disagreed with Dr. FitzGerald’s conclusions, noting that it looked only at healthy volunteers, “which is very different than studying people who actually have heart disease or other chronic illnesses who are taking various medications.” Those conditions or medications could affect the way aspirin works in the body, he said.

But Dr. Topol and Dr. FitzGerald did agree that there was little value in testing for whether someone was aspirin-resistant, in part because there was little evidence that knowing someone is resistant to aspirin will prevent a heart attack or stroke.

Representatives for Accumetrics, which sells a blood test, and Corgenix, which sells a urine test, maintained that there was value in determining how well aspirin worked in individual patients, and said more recent research on the issue has moved away from a stark determination of whether someone is resistant to aspirin. “This whole concept of drug resistance has moved past that term and moved into the level of response that someone has,” said Brian Bartolomeo, market development manager at Accumetrics.

Read More..