Notre Dame still the 1 in AP rankings

NEW YORK (AP) — Notre Dame is No. 1 in The Associated Press college football rankings with nothing left to do but wait to find out who its opponent in the national championship game will be.

Toward the bottom of the rankings, there was plenty of movement. Ten Top 25 teams lost this weekend, the most since Oct. 11, 2003.

No. 2 Alabama and No. 3 Georgia, both easy winners in rivalry games Saturday, held their spots in the rankings and will play for the SEC title in Atlanta next weekend.

Ohio State remained No. 4 after completing its perfect season with a victory against Michigan. The Buckeyes (12-0) are banned from the postseason because of NCAA sanctions.

Florida moved up a spot to No. 5 after beating Florida State.

Four teams from BCS non-automatic qualifying leagues are ranked. No. 18 Kent State and No. 19 Northern Illinois will play for the Mid-American Conference title Friday. No. 20 Utah State wrapped up its season as Western Athletic Conference champ.

No. 25 Boise State will play for a share of the Mountain West title against Nevada on Saturday.

The Big East had two teams fall out of the rankings, Rutgers and Louisville. The Scarlet Knights and Cardinals will play Thursday night with the Big East title and BCS bid on the line.

Boise State and No. 22 Northwestern moved back into the rankings.

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M.I.T. Lab Hatches Ideas, and Companies, by the Dozens

HOW do you take particles in a test tube, or components in a tiny chip, and turn them into a $100 million company?

Dr. Robert Langer, 64, knows how. Since the 1980s, his Langer Lab at the Massachusetts Institute of Technology has spun out companies whose products treat cancer, diabetes, heart disease and schizophrenia, among other diseases, and even thicken hair.

The Langer Lab is on the front lines of turning discoveries made in the lab into a range of drugs and drug delivery systems. Without this kind of technology transfer, the thinking goes, scientific discoveries might well sit on the shelf, stifling innovation.

A chemical engineer by training, Dr. Langer has helped start 25 companies and has 811 patents, issued or pending, to his name. That’s not too far behind Thomas Edison, who had 1,093. More than 250 companies have licensed or sublicensed Langer Lab patents.

Polaris Venture Partners, a Boston venture capital firm, has invested $220 million in 18 Langer Lab-inspired businesses. Combined, these businesses have improved the health of many millions of people, says Terry McGuire, co-founder of Polaris.

Along the way, Dr. Langer and his lab, including about 60 postdoctoral and graduate students at a time, have found a way to navigate some slippery territory: the intersection of academic research and the commercial market.

Over the last 30 years, many universities — including M.I.T. — have set up licensing offices that oversee the transfer of scientific discoveries to companies. These offices have become a major pathway for universities seeking to put their research to practical use, not to mention add to their revenue streams.

In the sciences in particular, technology transfer has become a key way to bring drugs and other treatments to market. “The model of biomedical innovation relies on research coming out of universities, often funded by public money,” says Josephine Johnston, director of research at the Hastings Center, a bioethics research organization based in Garrison, N.Y.

Just a few of the products that have emerged from the Langer Lab are a small wafer that delivers a dose of chemotherapy used to treat brain cancer; sugar-sequencing tools that can be used to create new drugs like safer and more effective blood thinners; and a miniaturized chip (a form of nanotechnology) that can test for diseases.

The chemotherapy wafer, called the Gliadel, is licensed by Eisai Inc. The company behind the sugar-sequencing tools, Momenta Pharmaceuticals, raised $28.4 million in an initial public offering in 2004. The miniaturized chip is made by T2Biosystems,  which completed a $23 million round of financing in the summer of 2011.

“It’s inconvenient to have to send things to a lab,” so the company is trying to develop more sophisticated methods, says Dr. Ralph Weissleder, a co-founder, with Dr. Langer and others, of T2Biosystems and a professor at Harvard Medical School.

FOR Dr. Langer, starting a company is not the same as it was, say, for Mark Zuckerberg with Facebook. “Bob is not consumed with any one company,” says H. Kent Bowen, an emeritus professor of business administration at Harvard Business School who wrote a case study on the Langer Lab. “His mission is to create the idea.”

Dr. Bowen observes that there are many other academic laboratories, including highly productive ones, but that the Langer Lab’s combination of people, spun-out companies and publications sets it apart. He says Dr. Langer “walks into the great unknown and then makes these discoveries.”

Dr. Langer is well known for his mentoring abilities. He is “notorious for replying to e-mail in two minutes, whether it’s a lowly graduate school student or the president of the United States,” says Paulina Hill, who worked in his lab from 2009 to 2011 and is now a senior associate at Polaris Venture Partners. (According to Dr. Langer, he has corresponded directly with President Obama about stem cell research and federal funds for the sciences.)

Dr. Langer says he looks at his students “as an extended family,” adding that “I really want them to do well.”

And they have, whether in business or in academia, or a combination of the two. One former student, Ram Sasisekharan, helped found Momenta and now runs his own lab at M.I.T. Ganesh Venkataraman Kaundinya is Momenta’s chief scientific officer and senior vice president for research.

Hongming Chen is vice president of research at Kala Pharmaceuticals. Howard Bernstein is chief scientific officer at Seventh Sense Biosystems, a blood-testing company. Still others have taken jobs in the law or in government.

Dr. Langer says he spends about eight hours a week working on companies that come out of his lab. Of the 25 that he helped start, he serves on the boards of 12 and is an informal adviser to 4. All of his entrepreneurial activity, which includes some equity stakes, has made him a millionaire. But he says he is mainly motivated by a desire to improve people’s health.

Operating from the sixth floor of the David H. Koch Institute for Integrative Cancer Research on the M.I.T. campus in Cambridge, Mass., Dr. Langer’s lab has a research budget of more than $10 million for 2012, coming mostly from federal sources.

The research in labs like Dr. Langer’s is eyed closely by pharmaceutical companies. While drug companies employ huge research and development teams, they may not be as freewheeling and nimble, Dr. Langer says. The basis for many long-range discoveries has “come out of academia, including gene therapy, gene sequencing and tissue engineering,” he says.

He has served as a consultant to pharmaceutical companies. Their large size, he says, can end up being an impediment.

“Very often when you are going for real innovation,” he says, “you have to go against prevailing wisdom, and it’s hard to go against prevailing wisdom when there are people who have been there for a long time and you have some vice president who says, ‘No, that doesn’t make sense.’ ”

Pharmaceutical companies are eager to tap into the talent at leading research universities. In 2008, for example, Washington University in St. Louis announced a $25 million pact with Pfizer to collaborate more closely on biomedical research.

But in some situations, the close — critics might say cozy — ties between business and academia have the potential to create conflicts of interest.

There was a controversy earlier this year when it was revealed that the president of the University of Texas M.D. Anderson Cancer Center owned stock in Aveo Oncology, which had announced earlier that the university would be leading clinical trials of one of its cancer drugs.  Last month, the University of Texas announced that he would be allowed to keep his ties with three pharmaceutical companies, including Aveo Oncology; his holdings will be placed in a blind trust.

Read More..

M.I.T. Lab Hatches Ideas, and Companies, by the Dozens

HOW do you take particles in a test tube, or components in a tiny chip, and turn them into a $100 million company?

Dr. Robert Langer, 64, knows how. Since the 1980s, his Langer Lab at the Massachusetts Institute of Technology has spun out companies whose products treat cancer, diabetes, heart disease and schizophrenia, among other diseases, and even thicken hair.

The Langer Lab is on the front lines of turning discoveries made in the lab into a range of drugs and drug delivery systems. Without this kind of technology transfer, the thinking goes, scientific discoveries might well sit on the shelf, stifling innovation.

A chemical engineer by training, Dr. Langer has helped start 25 companies and has 811 patents, issued or pending, to his name. That’s not too far behind Thomas Edison, who had 1,093. More than 250 companies have licensed or sublicensed Langer Lab patents.

Polaris Venture Partners, a Boston venture capital firm, has invested $220 million in 18 Langer Lab-inspired businesses. Combined, these businesses have improved the health of many millions of people, says Terry McGuire, co-founder of Polaris.

Along the way, Dr. Langer and his lab, including about 60 postdoctoral and graduate students at a time, have found a way to navigate some slippery territory: the intersection of academic research and the commercial market.

Over the last 30 years, many universities — including M.I.T. — have set up licensing offices that oversee the transfer of scientific discoveries to companies. These offices have become a major pathway for universities seeking to put their research to practical use, not to mention add to their revenue streams.

In the sciences in particular, technology transfer has become a key way to bring drugs and other treatments to market. “The model of biomedical innovation relies on research coming out of universities, often funded by public money,” says Josephine Johnston, director of research at the Hastings Center, a bioethics research organization based in Garrison, N.Y.

Just a few of the products that have emerged from the Langer Lab are a small wafer that delivers a dose of chemotherapy used to treat brain cancer; sugar-sequencing tools that can be used to create new drugs like safer and more effective blood thinners; and a miniaturized chip (a form of nanotechnology) that can test for diseases.

The chemotherapy wafer, called the Gliadel, is licensed by Eisai Inc. The company behind the sugar-sequencing tools, Momenta Pharmaceuticals, raised $28.4 million in an initial public offering in 2004. The miniaturized chip is made by T2Biosystems,  which completed a $23 million round of financing in the summer of 2011.

“It’s inconvenient to have to send things to a lab,” so the company is trying to develop more sophisticated methods, says Dr. Ralph Weissleder, a co-founder, with Dr. Langer and others, of T2Biosystems and a professor at Harvard Medical School.

FOR Dr. Langer, starting a company is not the same as it was, say, for Mark Zuckerberg with Facebook. “Bob is not consumed with any one company,” says H. Kent Bowen, an emeritus professor of business administration at Harvard Business School who wrote a case study on the Langer Lab. “His mission is to create the idea.”

Dr. Bowen observes that there are many other academic laboratories, including highly productive ones, but that the Langer Lab’s combination of people, spun-out companies and publications sets it apart. He says Dr. Langer “walks into the great unknown and then makes these discoveries.”

Dr. Langer is well known for his mentoring abilities. He is “notorious for replying to e-mail in two minutes, whether it’s a lowly graduate school student or the president of the United States,” says Paulina Hill, who worked in his lab from 2009 to 2011 and is now a senior associate at Polaris Venture Partners. (According to Dr. Langer, he has corresponded directly with President Obama about stem cell research and federal funds for the sciences.)

Dr. Langer says he looks at his students “as an extended family,” adding that “I really want them to do well.”

And they have, whether in business or in academia, or a combination of the two. One former student, Ram Sasisekharan, helped found Momenta and now runs his own lab at M.I.T. Ganesh Venkataraman Kaundinya is Momenta’s chief scientific officer and senior vice president for research.

Hongming Chen is vice president of research at Kala Pharmaceuticals. Howard Bernstein is chief scientific officer at Seventh Sense Biosystems, a blood-testing company. Still others have taken jobs in the law or in government.

Dr. Langer says he spends about eight hours a week working on companies that come out of his lab. Of the 25 that he helped start, he serves on the boards of 12 and is an informal adviser to 4. All of his entrepreneurial activity, which includes some equity stakes, has made him a millionaire. But he says he is mainly motivated by a desire to improve people’s health.

Operating from the sixth floor of the David H. Koch Institute for Integrative Cancer Research on the M.I.T. campus in Cambridge, Mass., Dr. Langer’s lab has a research budget of more than $10 million for 2012, coming mostly from federal sources.

The research in labs like Dr. Langer’s is eyed closely by pharmaceutical companies. While drug companies employ huge research and development teams, they may not be as freewheeling and nimble, Dr. Langer says. The basis for many long-range discoveries has “come out of academia, including gene therapy, gene sequencing and tissue engineering,” he says.

He has served as a consultant to pharmaceutical companies. Their large size, he says, can end up being an impediment.

“Very often when you are going for real innovation,” he says, “you have to go against prevailing wisdom, and it’s hard to go against prevailing wisdom when there are people who have been there for a long time and you have some vice president who says, ‘No, that doesn’t make sense.’ ”

Pharmaceutical companies are eager to tap into the talent at leading research universities. In 2008, for example, Washington University in St. Louis announced a $25 million pact with Pfizer to collaborate more closely on biomedical research.

But in some situations, the close — critics might say cozy — ties between business and academia have the potential to create conflicts of interest.

There was a controversy earlier this year when it was revealed that the president of the University of Texas M.D. Anderson Cancer Center owned stock in Aveo Oncology, which had announced earlier that the university would be leading clinical trials of one of its cancer drugs.  Last month, the University of Texas announced that he would be allowed to keep his ties with three pharmaceutical companies, including Aveo Oncology; his holdings will be placed in a blind trust.

Read More..

Morsi Urged to Retract Edict to Bypass Judges in Egypt

Tara Todras-Whitehill for The New York Times

A demonstrator takes a breather during protests in downtown Cairo on Saturday. More Photos »

CAIRO — The association of judges here called Saturday for courts across Egypt to suspend all but their most vital activities to protest an edict by President Mohamed Morsi granting himself unchecked power by setting his decrees above judicial review until the ratification of a new constitution.

The judges’ strike, which drew the support of the leader of the national lawyers’ association, would be the steepest escalation yet in a political struggle between the country’s new Islamist leaders and the institutions of the authoritarian government that was overthrown last year. As it spills into the courts and the streets, the dispute also increasingly threatens to undermine the credibility of Egypt’s political transition as well.

A council that oversees the judiciary denounced Mr. Morsi’s decree, which was issued Thursday, as “an unprecedented attack on judicial independence,” and urged the president to retract parts of the decree eliminating judicial oversight.

State news media reported that judges and prosecutors had already walked out in Alexandria, and there were other news reports of walkouts in Qulubiya and Beheira, but those could not be confirmed.

Outside Egypt’s high court in Cairo, the police fired tear gas at protesters who were denouncing Mr. Morsi and trying to force their way into the building, the second day in a row that protesters took to the streets over the presidential decree, which critics have decried as a return to autocracy.

Abdel Meguid Mahmoud, a prosecutor appointed by Mr. Morsi’s predecessor, Hosni Mubarak, declared to a crowd of cheering judges that the presidential decree was “null and void.” He denounced what he described as “the systematic campaign against the country’s institutions in general and the judiciary in particular.”

A coalition of disparate opposition leaders including the liberal former United Nations diplomat Mohamed ElBaradei, the leftist-nationalist Hamdeen Sabahy, and the former Mubarak-government foreign minister Amr Moussa formed a self-proclaimed National Salvation Front to oppose the decree. In addition to demanding the dissolution of the constitutional assembly, the group declared that it would not speak with Mr. Morsi until he withdrew his decree.

“We will not enter into a dialogue about anything while this constitutional declaration remains intact and in force,” Mr. Moussa said. “We demand that it be withdrawn and then we can talk.”

As the judges group called for a suspension of the courts, a growing number of lawyers filed claims demanding that the courts seek to overturn Mr. Morsi’s decree, joining the battle between the executive and judicial powers.

Advisers to Mr. Morsi, a former leader of the Muslim Brotherhood and Egypt’s first democratically elected president, defended his action, saying he was trying to prevent the courts from disbanding the Islamist-dominated constitutional assembly, which is writing a new constitution. The nation’s top courts had already dissolved the Islamist-led parliament and an earlier Islamist-led constituent assembly.

The advisers said a court decision on the new constitutional assembly had been expected as soon as next Sunday.

The judges’ group, as well as the newly unified secular opposition, have demanded that Mr. Morsi withdraw his decree, and that he disband and replace the current constitutional assembly. Many of the assembly’s non-Islamist members, including secularists and representatives of the Coptic Church, had already quit the body to protest the Islamists’ domination.

The increasingly vocal criticism of the assembly threatens to undermine the legitimacy of the ultimate charter, and has only increased the likelihood that the Islamist leaders may seek to pass and ratify it on their own, over the opposition of other groups, further damaging its credibility.

The opposition to the decree has also reinforced the fears of Islamists that judges appointed by former President Hosni Mubarak and the secular opposition were deliberately seeking to derail the process rather than accept their defeats at the polls.

Nevine Ramzy and Mai Ayyad contributed reporting.

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6 ways to tweet yourself out of a job

Hate your job? Want to leave without giving two weeks notice? Thanks to Twitter, it’s never been easier to get fired, says Rob Lammie at Mental Floss

Step 1: Drunk tweet
As any Spring Break partier knows, drinking impairs your judgment. It seems to have also impaired the judgment of Major League pitcher-turned-sports-radio-host Mike Bacsik, who put on quite a show during a San Antonio Spurs and Dallas Mavericks NBA game in April 2010. While watching the game, Bacsik bragged that he was “About 12 deep and some shots.” He proceeded to unleash a string of insults aimed at NBA commissioner David Stern, accused the refs of fixing the game, and even threatened to blow up the NBA’s offices. But the one that really got people riled up came after the Mavericks lost the game, when Bacsik tweeted: 

SEE MORE: Why popular kids make more money as adults

@MikeBacsik: “Congrats to all the dirty mexicans in San Antonio.”

After sobering up, Bacsik deleted the offending tweets and issued an apology. But it was too little, too late. Numerous people complained to his radio station, which first suspended Bacsik and later fired him. After his dismissal, he told ESPN Dallas, “When you tweet like that, it’s not a playful, harmless thing… I’m very sorry and will try my best for my actions to speak louder than my tweets.”

Step 2: Break the law (or just anger your governor)
Twitter has become a great tool for politicians to connect to the voting public. Former Mississippi Governor Haley Barbour, for one, has really embraced the technology as a way to share his opinions and views. For example, in December 2009, he sent out a tweet saying:

 @HaleyBarbour: “Glad the Legislature recognizes our dire fiscal situation. Look forward to hearing their ideas on how to trim expenses.”

Jennifer Carter, one of his Twitter followers who worked for the University of Mississippi Medical Center (UMC), read this message and offered up a suggestion on how Governor Barbour could personally save the taxpayers money:

“Schedule regular medical exams like everyone else instead of paying UMC employees overtime to do it when clinics are usually closed.” 

This “Oh, snap!” moment referred to an incident that had occurred three years earlier, when the governor requested the medical center open on a Saturday, when they were normally closed, and bring in a staff of 15-20 people who were paid overtime to administer his annual check-up. This happened before Carter worked for UMC and she was simply repeating what she had been told by other employees. 

SEE MORE: Does a shaved head give you an advantage in corporate America?

The governor’s office tracked down Carter and made a formal complaint to UMC, saying Carter had violated the Health Insurance Portability and Accountability Act, a privacy law that states no employee of a medical facility can reveal any information about a person’s “protected health information.” Some argued that Carter didn’t violate HIPAA, since she didn’t actually give out any information about the health of the governor. However, others believe that simply saying the governor had even visited a doctor is a violation. 

Semantics aside, UMC administrators said it was a violation, so they suspended Carter for three days without pay and strongly suggested she resign to avoid further disciplinary action, which she did.

SEE MORE: Facebook’s new jobs board: Is LinkedIn toast?

Step 3: Have an NSFW lifestyle
St. Louis-based blogger “The Beautiful Kind” had been writing online about her polyamorous sex life for years. Knowing that not everyone would agree with her chosen lifestyle, she was always very careful about maintaining her anonymity, especially when it came to the workplace. So when she signed up for Twitter, she wanted to be anonymous there as well. She thought that, thanks to the similarities between the two, it was like signing up for an online message board — you supplied your real name to the website privately, but could choose to be known publicly by your username only. But when she logged in for the first time and saw that, not only did it show her username (@TBK365), but also her real name on her profile, she immediately went back and removed it. 

Thinking she was now safely anonymous, she used Twitter to promote her blog and to discuss sexually explicit topics with her followers. However, when her boss at the non-profit group where she worked was told by upper management to do a Google search of all employees, TBK’s Twitter account information — with her real name still associated — came up on the Twitter tracking site topsy.com.

The next day, TBK was called into her boss’ office and fired on the spot. Afterwards, her former boss sent her a letter saying, “While I know you are a good worker and an intelligent person, I hope you try to understand that our employees are held to a different standard. When it comes to private matters, such as one’s sexual explorations and preferences, our employees must keep their affairs private.” Because Missouri is an at-will employment state, meaning employers can fire someone for just about any reason, TBK was SOL.

Step 4: Question company policy
When California Pizza Kitchen (CPK) traded in their standard white shirts for black ones, employee Tim Chantarangsu wasn’t happy with the change. So he tweeted @calpizzakitchen his opinion:

@traphik: “black button ups are the lamest s**t ever!!!”

He didn’t expect anyone to notice or care, but the next day he received a direct message from corporate asking what restaurant he worked for. He knew better than to respond, but they tracked him down anyway and he was fired. They not only referenced his tweet about the shirts, but also an earlier one where he had said he was getting ready to work at “Calipornia Skeetza Kitchen.” 

Little did they know that Chantarangsu is kind of a big deal on another social website, YouTube. Under the name TimothyDeLaGhetto2, Chantarangsu has hundreds of thousands of subscribers, accounting for over 10,500,000 views of his videos at the time. Of course he made a YouTube video telling his Twitter story and it has been viewed well more than 100,000 times. Shortly after the incident, he asked his followers to bombard CPK’s Twitter account with RTs (re-tweets) of his offending message, which they were more than happy to oblige.

Step 5: Make a celebrity look bad
During his five years on the job, Jon Barrett-Ingels had served a lot of celebrities as a waiter at Barney Greengrass, an upscale restaurant in Beverly Hills. One day, Jane Adams, star of the HBO series Hung, came in and had lunch to the tune of $ 13.44. Unfortunately, when the bill came, Adams realized she had left her wallet in the car. Ingels knew who she was, so he told her she could run out and grab it and come back. The actress left, but didn’t return. Instead, someone from her agency called the next day and paid the bill. However, they didn’t leave a tip. Ingels had recently signed up for Twitter and so, his sixth tweet to his 40 followers said:

@PapaBarrett: Jane Adams, star of HBO series “Hung” skipped out on a $ 13.44 check. Her agent called and payed the following day. NO TIP!!!” 

Over the next few weeks, Ingels started using Twitter to send out a few harmless observations about celebrities that came in to eat — mainly what they ordered or what they looked like that day. Then, out of the blue, Jane Adams came back to the restaurant. According to Ingels’ blog, she was clearly upset and begrudgingly slapped $ 3 on the bar for Ingels as a tip. Surprised, Ingels told the actress she really didn’t have to do that, but her gesture was appreciated. She allegedly replied with, “My friend read about it on Twitter!” before storming off. Adams complained about the tweet to management, so someone from Barney’s corporate started following Ingels on Twitter to see what he was up to. After reading his celebrity tweets, it didn’t take long before they gave him the boot.

Step 6: Don’t get hired in the first place
If you’ve followed steps 1 – 5 and you still have a job, here’s the ultimate way to make sure Twitter will keep you from gainful employment.

When recent college grad Skye Riley heard back from Cisco, the computer networking giant, about her job application, one of her first instincts was to tweet about it. Unfortunately, this is what she tweeted:

@theconnor: Cisco just offered me a job! Now I have to weigh the utility of a fatty paycheck against the daily commute to San Jose and hating the work.

The unfortunate part? An employee of Cisco, Tim Levad, came across her post while doing a Twitter search for Cisco. He replied to her by saying:

@timmylevad: Who is the hiring manager. I’m sure they would love to know that you will hate the work. We here at Cisco are versed in the web.

Riley’s story was the tweet heard round the world. It became a hot topic on tech blogs for weeks afterwards, with writers calling it the “Cisco Fatty” incident. She later claimed that the tweet was taken out of context — that part of her message was referring to a well-paid internship she had turned down — but it appears the damage had already been done. While only she and Cisco know what really happened, according to her online resume, she has never worked for the company.

 — Rob Lammie

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Undefeated: No. 4 Ohio State over No. 20 UM, 26-21

COLUMBUS, Ohio (AP) — Ohio State doesn't get to play in a bowl game.

But the Buckeyes have a sweet victory to carry them through a cold winter.

Carlos Hyde ran for 146 yards and No. 4 Ohio State's defense shut out 20th-ranked Michigan in the second half to grab a bruising 26-21 win on Saturday, completing an improbable 12-0 season for the Buckeyes.

Almost no one — up to and including first-year head coach Urban Meyer — expected such a rapid turnaround for the Buckeyes, who were just 6-7 last season with a loss to their archrivals in a transitional year when they were facing heavy NCAA penalties. A month after Meyer took the job last November, they were socked with a bowl ban after this season — and still ran the table.

Ohio State (12-0, 8-0 Big Ten) is ineligible for a BCS national title but still has an outside shot at finishing No. 1 in the final Associated Press Top 25 if other contenders lose. Michigan (8-4, 6-2) will now await a minor bowl bid.

Drew Basil matched his season output with four field goals and the defense did the rest, forcing three turnovers in the second half.

It was played before 105,899, the largest crowd ever to witness "The Game" in Columbus.

Meyer and his players were mobbed by thousands of fans who flooded the field after the Buckeyes' ninth victory in the last 11 years in the rivalry (the 2010 win was later vacated by the sanctions).

"It'll go down as one of the great teams in Ohio State history," Meyer exulted after the game.

Hyde also ran for a touchdown. Braxton Miller completed 14 of 18 passes for 189 yards and a score to Corey Brown, who had eight catches for 95 yards.

The Buckeyes had already clinched the Big Ten's Leaders Division, but aren't allowed to play in next Saturday's conference title game. Michigan needed a win to capture a share of the Legends Division with Nebraska, which will meet Wisconsin for the championship.

Now, about Ohio State can hope for is every other top team in the nation — including the only other unbeaten, top-ranked Notre Dame — to lose and lose badly in the coming weeks. A team banned from the postseason has never finished No. 1 in the AP Top 25 poll, and the Buckeyes are not eligible for the Bowl Championship Series rankings or coaches' poll.

Michigan's Denard Robinson had a brilliant first half but was largely invisible in the second. He totaled 122 yards on 10 carries, but had lost 2 yards on his four carries after halftime.

Devin Gardner, the other half of Michigan's quarterback tandem, was 11 of 20 for 171 yards with an interception and a touchdown pass.

For the Buckeyes, the game will be remembered for the staunch defense played when most needed. Michigan had 26 plays for 219 yards in first half, then ran 21 plays for a net of 60 yards in the second.

For the Wolverines, there will be lingering questions for coach Brady Hoke, who wore short sleeves in the freezing temperatures — just like Woody Hayes used to during the 1960s and 1970s in the rivalry.

With his team ahead 21-20, Hoke called timeout on fourth and 2 near midfield on Michigan's first possession of the second half. Robinson then ran up the middle, but ran into linebacker Ryan Shazier for a two-yard loss.

That cost the Wolverines the lead as Ohio State drove to the Michigan 11 before settling for Basil's 28-yard field goal, putting the Buckeyes up 23-21.

The teams traded possessions and turnovers for the next 12 minutes. Robinson fumbled after Bradley Roby's helmet hit the ball on a tackle, with Nathan Williams recovering for the Buckeyes.

Early in the fourth quarter, Miller was sacked on third and 9 at the Michigan 28 and coughed up the ball to Frank Clark.

But in each case the other team didn't take advantage.

The Buckeyes drove to a second and 1 at the Michigan 4 but a sack and a high snap preceded Basil missing a 39-yard field goal attempt.

The Wolverines lost 2 yards on third and 1 and were forced to punt after Miller's fumble.

Ohio State did pick up points on its next chance after a turnover.

Gardner fumbled when hit by Johnathan Hankins with 8:19 left, with Travis Howard pouncing on the loose ball after several players had a shot at it. Taking over at the Wolverines' 10, the Buckeyes could not move the ball and were forced to settle for Basil's fourth field goal of the game, a 25-yarder with 6:26 remaining, for a 26-21 lead.

That matched Basil's production the entire season. He came into the game 4 for 6 on the year.

Gardner then tossed a floater that was intercepted by C.J. Barnett, ending the Wolverines final threat as Hyde carried the ball repeatedly and the Buckeyes played keep-away to the finish.

The Buckeyes, who were without captain and top quarterback-sacker John Simon, appeared to grab control early. They scored on the opening possession, with Miller's 52-yard, play-action pass to Devin Smith setting up Hyde's 3-yard plunge.

Michigan came right back and drove to the Ohio State 22 but on third and 8 Adolphus Washington — playing because Simon was out — stripped the ball as Gardner was passing, with Zach Boren recovering.

But the Wolverines forced a punt and then needed just three plays to cover 83 yards with Gardner tossing a short pass in front of the Michigan bench to Roy Roundtree, who straight-armed Barnett and sped down the sideline accompanied by teammate Drew Dileo. The 75-yard pass play was Michigan's longest of the season.

With Miller hitting all five of his passes, the Buckeyes were stymied by three penalties in four plays and had to settle for Basil's 41-yard field goal.

Brown muffed a punt catch that was recovered by Marvin Robinson for Michigan and the Wolverines were right back in business at the Ohio State 25. On the sixth play, Gardner kept for the short TD and a 14-10 lead.

Michigan took over at its own 25 with 90 seconds left. Robinson followed two fullbacks around left end for an eight-yard gain and it appeared Hoke might just be content with running out the clock. But on second down, Robinson followed a convoy around the right side. Ohio State defensive backs Christian Bryant and Travis Howard arrived at the exact same instant, colliding while Robinson popped free. He raced untouched the rest of the way on the 67-yard TD, the 91st touchdown he has accounted for in his glittering career to pass Chad Henne for the school record.

Between the first and second quarters, Ohio State honored its 2002 national championship team. After a highlight clip was shown to a roaring crowd, several players hoisted coach Jim Tressel to their shoulders and carried him out of the end zone.

No boos were heard, or else they were drowned out — even though it was Tressel's NCAA violations which will keep this year's unbeaten Buckeyes home in the postseason.

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Follow Rusty Miller on Twitter: http://www.twitter.com/rustymillerap

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Nintendo’s Wii U Takes Aim at a Changed Video Game World

REDMOND, Wash.

TUCKED in the woods here, west of State Route 520, is a little piece of the Mario Kingdom.

Behind the unassuming doors is the business built by Mario, the pudgy plumber, and Luigi, his lanky brother, as well as characters like Link, wielder of the mystical Master Sword, and Princess Zelda, of the royal family of Hyrule. All of them, and more, are the pixelated children of Shigeru Miyamoto, the Walt Disney of video games and creative genius of the Nintendo Company of Japan.

But while Mr. Miyamoto is dreaming his dreams across the Pacific, an army of marketing types is at work here in Redmond, inside the shiny new headquarters of Nintendo of America. This palace of play is quiet, but there’s trouble brewing in the world around it: three decades after the mustachioed Mario burst into arcades via Donkey Kong, plucking countless quarters from people’s pockets, the kingdom is under siege.

Nintendo’s enemies have arrived by battalions. Angry Birds, Fruit Ninja and other inexpensive, downloadable games, particularly for cellphones and tablets, have invaded its turf. Changing tastes and technology have called into question the economics of traditional game consoles, whether from Nintendo or Microsoft, maker of the Xbox. Nintendo recently posted the first loss in its era as a video games company, a prospect that would have been unimaginable only a few years ago. And while game consoles aren’t going away, analysts are skeptical that the business will regain its former stature soon.

All of which makes Nintendo’s next move, and what is happening here, so crucial. Nintendo counterattacked on Nov. 18, when a new version of its Wii game console arrived in stores nationwide.

The original Wii, the first wireless, motion-capturing console, was nothing less than revolutionary. The simplicity of its controller, which Mr. Miyamoto helped design, attracted new audiences like women and older people. Customers lined up in stores for it — and then it simply faded. Now, the new console, the Wii U, may be Nintendo’s last, best hope for regaining its former glory. Executives are hoping for a holiday hit, and perhaps even another runaway success.

Initial demand appears high. GameStop, the video game retailer, opened 3,000 stores at midnight on Thursday for Black Friday sales, and before long almost all its Wii Us were sold out, according to Tony Bartel, GameStop’s president. “I think people are starving for innovation, and Wii U is giving them that innovation," Mr. Bartel says. 

THE Wii U is a recognition that the living room is no longer the province of a single screen. More people, particularly the young, now watch TV with a smartphone or tablet in hand, the better to tweet a touchdown or update their Facebook status during a commercial. The Wii U looks like a mash-up of an iPad and a traditional console, with a touch screen embedded in the middle. It’s no mere festival of joysticks, buttons and triggers.

But will it be the blowout that Nintendo needs? Many industry veterans and game reviewers are skeptical. They question whether the Wii U can be as successful as the original, now that many gamers have moved on to more abundant, cheaper and more convenient mobile games.

“I actually am baffled by it,” Nolan K. Bushnell, the founder of Atari and the godfather of the games business, says of the Wii U. “I don’t think it’s going to be a big success.”

The bigger question is what the future holds for any of the major game systems, including new ones that Sony and Microsoft are expected to release next year. Echoing other industry veterans, Mr. Bushnell says that consoles are already delivering remarkable graphics and that few but the most hard-core players will be willing to pay hundreds of dollars for a new game box.

“These things will continue to sputter along, but I really don’t think they’ll be of major import ever again,” he says. “It feels like the end of an era to me.”

Nintendo is unbowed. Mr. Miyamoto was involved in developing the original Wii, and had a role in the Wii U as well. He rarely gives interviews, and was unavailable for comment for this article.

But one recent evening in Redmond, Corey Olcsvary, a Nintendo product marketing specialist, was slashing his fingers across the touch screen on the GamePad, as the Wii U controller is called, casting “throwing stars” at a ninja gang that sprang from the corners of a giant TV screen. In another game, a group of players chased Mario — one of the most popular video game characters ever — around a maze shown on a TV while Mr. Olcsvary stared at a bird’s-eye view of the maze on his GamePad and tried to help Mario dodge his pursuers. The players shouted when they caught sight of Mario’s red overalls and cheered when they tackled him.

Starting in December, people will also be able to use the GamePad as a remote control to set recordings and change channels on their cable and satellite TV services.

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Protests Erupt After Egypt’s Leader Seizes New Power

CAIRO — Opponents of President Mohamed Morsi were reported to have set fire to his party’s offices in several Egyptian cities on Friday in a spasm of protest and clashes after he granted himself broad powers above any court declaring himself the guardian of Egypt‘s revolution, and used his new authority to order the retrial of Hosni Mubarak.

Maya Alleruzzo/Associated Press

Egyptian protesters chanted antigovernment slogans and waved a national flag in Tahrir Square on Friday.

In the Mediterranean city of Alexandria, the opponents of the Muslim Brotherhood’s Freedom and Justice Party clashed with followers of Mr. Morsi, an Islamist, who won Western and regional plaudits only days ago for brokering a cease-fire to halt eight days of lethal exchanges between Israeli forces and militants in the Gaza Strip.

Mr. Morsi, Egypt’s first democratically elected president, portrayed his decree assuming the new powers as an attempt to fulfill popular demands for justice and protect the transition to a constitutional democracy. He said it was necessary to overcome gridlock and competing interests. But the unexpected breadth of the powers he seized raised immediate fears that he might become a new strongman.

“We are, God willing, moving forward, and no one stands in our way,” Reuters quoted Mr. Morsi as saying on Friday said in a suburban mosque here after Friday prayers.

“I fulfill my duties to please God and the nation and I take decisions after consulting with everyone,” he said. “Victory does not come without a clear plan and this is what I have.”

He spoke as state television reported that his party’s offices in the Suez Canal cities of Suez, Port Said and Ismailia had been burned as his foes rampaged. Thousands of people protesting Mr. Morsi’s power grab gathered in Tahrir Square here — the focal point of protests that, last year, swept away Mr. Mubarak. Elsewhere in the capital, the president’s supporters massed in even larger numbers outside the presidential palace where Mr. Morsi said his aim was “to achieve political, social and economic stability.”

“I am for all Egyptians. I will not be biased against any son of Egypt,” he said on a stage outside the presidential palace, Reuters, reported, adding he was working for social and economic stability. “Opposition in Egypt does not worry me, but it has to be real and strong,” he said.

Sounding defensive at times and employing some of the language favored by his autocratic predecessor, Mr. Morsi justified his power grab as necessary to move Egypt’s revolution forward.

“The people wanted me to be the guardian of these steps in this phase,” he said, reminding his audience that he was freely elected after a contest “that the whole world has witnessed.”

“I don’t like, and don’t want — and there is no need — to use exceptional measures,” he said. “But those who are trying to gnaw the bones of the nation,” he added, “must be held accountable.”

News reports said clashes spread from Alexandria to the southern city of Assyut. But the severity of the clashes was not immediately clear.

Mr. Morsi’s new powers prompted one prominent adversary, Mohamed ElBaradei, to say on Twitter: “Morsi today usurped all state powers & appointed himself Egypt’s new pharaoh.”

“An absolute presidential tyranny,” Amr Hamzawy, a liberal member of the dissolved Parliament and prominent political scientist, wrote in an online commentary. “Egypt is facing a horrifying coup against legitimacy and the rule of law and a complete assassination of the democratic transition.”

Mr. Morsi issued the decree on Thursday at a high point in his five-month-old presidency, when he was basking in praise from the White House and around the world for his central role in negotiating a cease-fire that the previous night had stopped the fighting in the Gaza Strip.

But his political opponents immediately called for demonstrations on Friday to protest his new powers. “Passing a revolutionary demand within a package of autocratic decisions is a setback for the revolution,” Abdel Moneim Aboul Fotouh, a more liberal former leader of the Muslim Brotherhood and a former presidential candidate, wrote online. And the chief of the Supreme Constitutional Court indicated that it did not accept the decree.

In Washington on Thursday, the State Department spokeswoman, Victoria Nuland, released a statement saying: “The decisions and declarations announced on November 22 raise concerns form many Egyptians and the international community,” and noting that “one of the aspirations of the revolution was to ensure that power would not be overly concentrated in that hands of any one person or institution.” The statement called for resolution “through democratic dialogue.”

David D. Kirkpatrick and Kareem Fahim reported from Cairo and Alan Cowell from Paris. Mayy El Sheikh contributed reporting.

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Fired colleague of UBS rogue trader Adoboli opens betting site

LONDON (Reuters) – A former senior trader at UBS, sacked for failing to prevent colleague Kweku Adoboli from perpetrating the biggest fraud in British history, has set up a gambling website.

In a decision likely to be seized upon by critics who say traders have often made casino-style bets, John Hughes started his gambling firm even though his website said his old job had “removed all sense of optimism from his character”.

Adoboli, his former subordinate now serving seven years in jail for running up losses of $ 2.3 billion, argued during his trial that his own behavior was the result of a risky trading culture encouraged by senior colleagues, and his lawyers alleged that Hughes had played a major role in “off-book” trading.

Hughes admitted he had known of Adoboli’s scheme to hide his giant losses and that he had booked several fictitious trades himself, but denied knowledge of some of Adoboli’s biggest multi-billion dollar trades.

Hughes said he had chosen to call his new gambling website ‘BetsofMates’, a play on the expression “Best of Mates”.

That may grate with Adoboli who complained that his colleagues, including Hughes, had “sold me down the river” after a meeting at which he said it was decided he alone would carry the can for the huge losses.

Hughes and the others said they had no memory of such a meeting.

“We’re not a standard bookie,” Hughes said of his new website, which enables users to play against each other in leagues, with each player placing bets of between two and 200 pounds.

“We facilitate competition. The emphasis is a lot more on competition than yield enhancement,” he told Reuters on Thursday.

The former senior trader on the Exchange Traded Funds desk at UBS in London said Adoboli’s conviction was “just incredibly sad”. He declined to comment further.

Despite a large salary and bonus, Adoboli was himself an avid gambler and lost 123,000 pounds ($ 200,000) on spread-betting in the year before his arrest.

One prosecutor accused him of being addicted to gambling to which Adoboli countered that spread-betting was common among City traders “like a taxi driver driving his own taxi home”.

Hughes’ profile on his new firm’s website says that “seven years in the City (had) removed all sense of optimism from his character, and made him absurdly superstitious.”

He told Reuters such feelings had arisen “sitting there watching the markets for seven years and watching different news hit the tapes and obviously the last seven years haven’t been the easiest in the financial markets.”

Britain’s Gambling Commission granted a license to his pool betting company ‘Bets of Mates Limited’, which is registered to an East London address, in September 2012, two months before Adoboli was convicted.

(Editing by Andrew Osborn)

Internet News Headlines – Yahoo! News

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NHL cancels games through Dec. 14, All-Star game

NEW YORK (AP) — The NHL has called off all games through Dec. 14, plus the 2013 NHL All-Star Weekend scheduled for Jan. 26-27 in Columbus, Ohio.

The league made the announcement Friday, the 69th day of the NHL's lockout of its players.

The new cancellations come as little surprise. The two sides had an unproductive negotiating session on Wednesday that produced no movement to break an impasse over splitting more than $3 billion in revenue and also player contracts.

"We've identified what's important to players, but they seem to be so far at least unwilling to treat those concerns in a serious way," union head Donald Fehr said after the last round of talks, at which the union presented a new proposal to the league.

A total of 422 regular-season games, more than 34 percent of the season, have now been lost.

NHL Deputy Commissioner Bill Daly said losing the 2013 NHL All-Star Weekend in Columbus is "extremely disappointing."

"We feel badly for NHL fans and particularly those in Columbus, and we intend to work closely with the Blue Jackets organization to return the NHL All-Star events to Columbus and their fans as quickly as possible," Daly said in a statement Friday.

The Columbus Blue jackets, the club hosting the All-Star game and the skills competition, said fans with tickets to events on that weekend could receive refunds.

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